Here you’ll see a really nice example of what modern microscopy actually allows you to do if combined with additional, fitting, techniques
When we’re wounded, our bodies rush to repair the damage. First, there’s a blood clot that forms quickly and acts as a temporary seal. Then follows the more gradual process of angiogenesis – the growth of new blood vessels to replace those that are injured. This image is of a wound healing on a mouse. It was captured using a new form of fluorescence microscopy, which involves staining the tissue with chemicals that make it fluoresce, and then taking a picture that shows only the fluorescence. At the top is the blood clot in the open wound, while the strands beneath are newly grown capillaries [the smallest blood vessels] extending into the muscle. This technique enables us to understand the complex mechanisms of wound healing better than ever before.
Deep imaging within tissue (over 300 μm) at micrometer resolution has become possible with the advent of…
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So here’s another short one for the microscopy series. The “what was before” the microscope part of it, if you want to phrase it that way.
The central part of a microscope is the lens. But a lens is also a plant (Lens culinaris) and the name of it’s very own fruit, called Lentia in latin. So how do these two connect, you might ask. And that is really straight forward. In the 1st century AD the romans started experimenting with various shapes of glass, not only to put them in windows but also convert them into beautiful pieces of artwork and jewlery for example. One of the shapes the cam up with resembled that of a lens, a common edible at that time. So it was roundish, flat at the edges and growing in thickness towards the center with a rather regular curvature. When those romans looked through that see-through, lens shaped obejct they discouvered that objects on the far side of it will appear bigger, and that was the very moment in history the magnifying glass, or lens, was born.
Without a lens, no microscope, no telescope, no binocular, in fact not even normal glasses would work. So I guess once again we have to be thankful for those great inventions that date back over centuries, without which our society would just not quite work as it does.
So now that you know where the lens comes from, my next post will focus a bit more on some of the other things I just mentioned. Namely binoculars, telescopes, magnifying glasses, regular glasses and what seperates them from what we consider a microscope.
I’m so sorry for not blogging for so long, that will change now, since I am going to try summing up microscopy. Not quite an easy topic, but since I’m dealing with microscopes nearly every day, and teaching every once in a while, and I found that people using microscopes often know too little about how they work and where they come from. So the next couple of posts will focus on just that, history and principles of microscopy. Enjoy and cheers